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Scientists from Spain and China have successfully repaired the blood-brain barrier in Alzheimer's-model mice, enabling the brain to naturally clear amyloid-beta plaques and reverse cognitive decline. "After just three drug injections, mice with certain genes that mimic Alzheimer's showed a reversal of several key pathological features," adds ScienceAlert. From the report: Within hours of the first injection, the animal brains showed a nearly 45 percent reduction in clumps of amyloid-beta plaques, a hallmark of Alzheimer's disease. The mice had previously shown signs of cognitive decline, but after all three doses, the animals performed on par with their healthy peers in spatial learning and memory tasks. The benefits lasted at least six months. These preclinical results don't guarantee success in humans, but they're an encouraging start, which the authors say "heralds a new era" in drug research. "The therapeutic implications are profound," claim the international team of researchers, co-led by scientists at the Institute for Bioengineering of Catalonia (IBEC) and the West China Hospital Sichuan University (WCHSU). The findings have been published in Signal Transduction and Targeted Therapy.

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An anonymous reader quotes a report from the Conversation: Sound waves at frequencies above the threshold for human hearing are routinely used in medical care. Also known as ultrasound, these sound waves can help clinicians diagnose and monitor disease, and can also provide first glimpses of your newest family members. And now, patients with conditions ranging from cancer to neurodegenerative diseases like Alzheimer's may soon benefit from recent advances in this technology. I am a biomedical engineer who studies how focused ultrasound -- the concentration of sound energy into a specific volume -- can be fine-tuned to treat various conditions. Over the past few years, this technology has seen significant growth and use in the clinic. And researchers continue to discover new ways to use focused ultrasound to treat disease. [...] Research on focused ultrasound has primarily focused on the most devastating and prevalent diseases, such as cancer and Alzheimer's disease. However, I believe that further developments in, and increased use of, focused ultrasound in the clinic will eventually benefit patients with rare diseases. One rare disease of particular interest for my lab is cerebral cavernous malformation, or CCM. CCMs are lesions in the brain that occur when the cells that make up blood vessels undergo uncontrolled growth. While uncommon, when these lesions grow and hemorrhage, they can cause debilitating neurological symptoms. The most common treatment for CCM is surgical removal of the brain lesions; however, some CCMs are located in brain areas that are difficult to access, creating a risk of side effects. Radiation is another treatment option, but it, too, can lead to serious adverse effects. We found that using focused ultrasound to open the blood-brain barrier can improve drug delivery to CCMs. Additionally, we also observed that focused ultrasound treatment itself could stop CCMs from growing in mice, even without administering a drug. While we don't yet understand how focused ultrasound is stabilizing CCMs, abundant research on the safety of using this technique in patients treated for other conditions has allowed neurosurgeons to begin designing clinical trials testing the use of this technique on people with CCM. With further research and advancements, I am hopeful that focused ultrasound can become a viable treatment option for many devastating rare diseases.

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mspohr shares a report from Futurism: Western automotive and green energy executives who visit China are returning humbled -- and even terrified. As The Telegraph reports, the executives are warning that the country's heavily automated manufacturing industry could quickly leave Western nations behind, especially when it comes to electric vehicles. "We are in a global competition with China, and it's not just EVs," Ford CEO Jim Farley told The Verge last month. "And if we lose this, we do not have a future at Ford." Some companies are giving up on new initiatives altogether, with the founder of mining company Fortescue, Andrew Forrest, claiming that his recent trip to China led to him abandoning attempts to produce EV powertrains in-house. "There are no people -- everything is robotic," he told The Telegraph. Other executives recalled touring "dark factories" that don't even need to keep the lights on, as most work is being done around the clock by robots. "You get this sense of a change, where China's competitiveness has gone from being about government subsidies and low wages to a tremendous number of highly skilled, educated engineers who are innovating like mad," British energy supplier Octopus CEO Greg Jackson told the newspaper. According to recent figures by the International Federation of Robotics, China has deployed orders of magnitude more industrial robots than Germany, the US, and the UK.

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Norway has effectively achieved its 2025 goal of 100% electric new car sales, prompting the government to declare "mission accomplished" and propose scaling back EV tax exemptions to reflect a mature market. "We have had a goal that all new passenger cars should be electric by 2025, and ... we can say that the goal has been achieved," announced Finance Minister Jens Stoltenberg. Electrek reports: With the finish line in sight, the Norwegian government is now fine-tuning its approach. The current incentive program maintains the crucial VAT exemption for EVs, but only up to a purchase price of 500,000 Norwegian kroner (approximately $49,000 USD). This move is designed to target more expensive, luxury EVs, ensuring that the incentive benefits a broader range of consumers. However, the latest budget proposal aims to reduce the EV tax exemption to vehicles costing 300,000 Norwegian kroner (~30,000 USD). This would apply for 2026, and then the tax exemption would completely end in 2027. Additionally, the government plans to increase taxes on new gasoline and diesel cars, further widening the cost gap between polluting and zero-emission vehicles. However, the proposal still needs to be adopted by Norway's government, and there is some opposition. EV associations are advocating for a more extended phase-out period to ensure that the adoption rate doesn't decline.

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Boris Johnson's former adviser claims that China infiltrated a key UK government data-transfer network for years, compromising highly classified materials and prompting a Whitehall cover-up that prioritized Chinese investment over national security. The Times reports: Dominic Cummings, who served as a senior adviser to Boris Johnson, said that he and the then prime minister were informed about the breach in 2020 but that there had subsequently been a cover-up. He said he was warned at the time that disclosing some specific details of the breach would be a criminal offence. He claimed that the breach included some "Strap" material, which is the government term for the highest level of classified information. The breach, which was confirmed by two other senior Whitehall sources, was said to have been connected to a Chinese-owned company involved in Britain's critical national infrastructure. Tom Tugendhat, a former Tory security minister, supported Cummings's account. Cummings said that he and Johnson were informed of the breach in the "bunker" of No 10 -- a reference to the secure room in Downing Street. He told The Times: "The cabinet secretary said, 'We have to explain something; there's been a serious problem', and he talked through what this was. "And it was so bizarre that, not just Boris, a few people in the room were looking around like this -- 'Am I somehow misunderstanding what he's saying? Because it sounds f***ing crazy.'" He added: "What I'm saying is that some Strap stuff was compromised and vast amounts of data classified as extremely secret and extremely dangerous for any foreign entity to control was compromised. "Material from intelligence services. Material from the National Security Secretariat in the Cabinet Office. Things the government has to keep secret. If they're not secret, then there are very, very serious implications for it."

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An anonymous reader quotes a report from The Guardian: People in London could be hiring driverless taxis from Waymo next year, after the US autonomous vehicle company announced plans to launch its services there. The UK capital will become the first European city to have an autonomous taxi service of the kind now familiar in San Francisco and four other US cities using Waymo's technology. The launch pits an innovation sometimes dubbed the "robotaxi" against London's famous black cabs, which can trace their history back to the first horse-drawn hackney coaches of the Tudor era. But a representative of the capital's cab drivers said they were not concerned by the arrival of a "fairground ride" and questioned the reliability of driverless vehicles. Waymo said its cars were now on their way to London and would start driving on the capital's streets in the coming weeks with "trained human specialists," or safety drivers, behind the wheel. The company, originally formed as a spin-off from Google's self-driving car program, said it would scale up operations and work closely with Transport for London and the Department for Transportto obtain the permits needed to offer fully autonomous rides in 2026. Uber and the UK tech company Wayve have also announced their own plans to trial their driverless taxis in the capital next year, after the British government said it would accelerate rules allowing public trials to take place before legislation enabling self-driving vehicles passes in full.

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Mozilla is testing a free, built-in VPN for Firefox that routes traffic through Mozilla-managed servers directly in the browser. The Register reports: According to a staff post on Mozilla Connect, the company's idea-sharing platform, Firefox VPN is still an experimental feature in the early stages of development, but users will be selected at random to test it "over the next few months." Moz describes the feature as one that will sit beside the search bar on Firefox, routing web traffic through a Mozilla-managed VPN server, concealing the user's real IP address while adding a layer of encryption to their communications. Firefox VPN is a different project entirely from Mozilla VPN, a separate, paid-for product. The Firefox version will be free to use and confined to the browser itself, while Mozilla VPN can be used by up to five devices at a time. The Moz staffer on the product team who announced the feature said of the upcoming beta test: "We'll start simple, then gradually add new capabilities while learning how it impacts browsing, usage, and overall satisfaction. "Our long-term vision is ambitious: to build the best VPN-integrated browser on the market." In response to feedback, the staffer noted that while it will be a desktop browser feature first, "mobile is definitely a natural next step."

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Anthropic is projecting its annualized revenue run rate to soar from roughly $7 billion today to as much as $26 billion in 2026, driven by rapid enterprise adoption of its Claude AI models. Reuters reports: Anthropic debuted a new version of its cheapest AI model, Haiku, on Wednesday, as part of a broader effort to appeal to companies that are looking for capable AI systems that are dramatically cheaper than its more advanced models. The Haiku 4.5 model sells for about one-third the price of Sonnet 4, one of its medium-sized models. The revenue projections underscore continued strong demand for generative AI tools among businesses and help explain investor enthusiasm, even as AI spending, especially in infrastructure buildout, comes under scrutiny. Some people worry the level of investment might be unsustainable. Fueling the expansion is the uptake of enterprise products, which are built for organizations. Anthropic has more than 300,000 business and enterprise customers, which account for about 80% of its revenue.

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An anonymous reader quotes a report from BleepingComputer: U.S. cybersecurity company F5 disclosed that nation-state hackers breached its systems and stole undisclosed BIG-IP security vulnerabilities and source code. The company states that it first became aware of the breach on August 9, 2025, with its investigations revealing that the attackers had gained long-term access to its system, including the company's BIG-IP product development environment and engineering knowledge management platform. F5 is a Fortune 500 tech giant specializing in cybersecurity, cloud management, and application delivery networking (ADN) applications. The company has 23,000 customers in 170 countries, and 48 of the Fortune 50 entities use its products. BIG-IP is the firm's flagship product used for application delivery and traffic management by many large enterprises worldwide. [...] F5 is still reviewing which customers had their configuration or implementation details stolen and will contact them with guidance. To help customers secure their F5 environments against risks stemming from the breach, the company released updates for BIG-IP, F5OS, BIG-IP Next for Kubernetes, BIG-IQ, and APM clients. Despite any evidence "of undisclosed critical or remote code execution vulnerabilities," the company urges customers to prioritize installing the new BIG-IP software updates.

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Google is introducing new recovery tools that aim to make it less frustrating to regain access when you're locked out of your account. The Verge: Instead of answering security questions or entering a recovery email address, Google's new security features allow account holders to verify their identity using a linked mobile number, or trusted friends or family members. The Recovery Contacts feature enables users to designate people to confirm their identity in order to regain access to accounts after getting hacked or losing their password or passkey. Google didn't specify how the verification process works, but says the feature provides "a simple and secure way to regain access when standard recovery methods fail." Recovery Contacts is available for eligible personal Google accounts, and can be found under the Security option in the account settings.

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Alexis Ohanian, who helped build Reddit, says much of the internet has become dominated by bots and AI. Speaking on the podcast TBPN, he described the internet as increasingly "quasi-AI" and filled with what he called "LinkedIn slop." Ohanian referenced dead internet theory, the assertion that bot activity exceeds human activity on the web. In September, Sam Altman, OpenAI's CEO, posted that while he had not taken the theory seriously, he now sees "a lot of LLM-run twitter accounts."

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The U.S. passport has fallen out of the top 10 most powerful passports globally for the first time in 20 years in the latest edition of the Henley Passport Index, which ranks nations based on the number of destinations a traveler can visit without needing a visa. From a report: The U.S. ranking is on a steep downward trend, with the U.S. passport now in 12th spot, tied with Malaysia, having already fallen from seventh place last year to 10th place in July. A decade ago, the U.S. passport topped the index. Christian H. Kaelin, chairman of Henley & Partners and creator of the index, said in a news release on Tuesday that the declining strength of the U.S. passport signaled a "fundamental shift in global mobility and soft power dynamics." Kaelin added: "Nations that embrace openness and cooperation are surging ahead, while those resting on past privilege are being left behind."

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The UK should be prepared to cope with weather extremes as a result of at least 2C of global warming by 2050, independent climate advisers have said. BBC: The country was "not yet adapted" to worsening weather extremes already occurring at current levels of warming, "let alone" what was expected to come, the Climate Change Committee (CCC) wrote in a letter addressed to the government. The committee said they would advise that the UK prepare for climate change beyond the long-term temperature goal set out in the Paris Agreement. The letter came as the World Meteorological Organization (WMO) confirmed that 2024 had seen a record rise of carbon dioxide (CO2) in the atmosphere. CO2 is the gas mainly responsible for human-caused climate change and is released when fossil fuels are burnt, as well as other activities.

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Almost 70% of adults in the US would be deemed to have obesity based on a new definition, research suggests. From a report: The traditional definition of obesity, typically based on having a body mass index (BMI) of 30 or greater, has long been contentious, not least as it does not differentiate between fat and muscle. In an effort to tackle the issue, in January medical experts from around the world called for a new definition to be adopted. This would encompass people either with a BMI greater than 40; or those with a high BMI and at least one raised figure for measures such as waist circumference, waist-to-hip ratio, or waist-to-height ratio; or those with two such raised figures regardless of BMI; or those with direct measures of excess body fat based on scans. In addition, they said obesity should be split into two categories: clinical obesity -- where there are signs of illness -- and pre-clinical obesity, where there are not. Now research suggests the revamped definition could result in a dramatic rise in the prevalence of obesity among adults in the US.

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Math teachers across American schools are contending with a classroom disruption that has proven impossible to contain. The numbers six and seven now trigger instant pandemonium among students. They scream the phrase and perform a palms-up seesaw hand gesture whenever the numbers appear in equations or instructions. Teachers have begun avoiding breaking students into groups of six or seven or asking them to turn to page 67. The meme has no meaning, reports WSJ. That absence of meaning is the point. The phenomenon traces back to late last year when Philadelphia rapper Skrilla released "Doot Doot (6 7)," a song referencing 67th street where his friends grew up. The phrase spiraled into youth culture in March through a viral video of a boy with forward-swept hair lurching toward a camera to deliver an animated "six seven." Skrilla is now touring venues where audiences wait for the six-seven line. Some teachers have attempted to neutralize the meme by saying it themselves.

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Apple has rebranded its streaming service Apple TV+ to simply Apple TV, further blurring the already confusing line between the Apple TV device, the Apple TV app, and the Apple TV service. As John Gruber notes, users can now "watch Apple TV in Apple TV on Apple TV." From Daring Fireball: In some ways, I get it. Like, if you're telling someone how much you enjoy Slow Horses and they ask how to watch it, it's more natural and conversational to just say "It's on Apple TV." That's what most people say. That's what I say -- and as part of my job, I completely understand the difference between Apple TV the device, Apple TV the (free) app, and Apple TV+ the (paid) streaming service. But right there in Apple's own "About Apple TV" description, you see just how overused "Apple TV" now is. You can watch Apple TV in Apple TV on Apple TV -- the paid service in the free app on the set-top box. But you can watch any streaming service you want on the box, in that service's own app. But many of those services are also available in the Apple TV app. And the Apple TV streaming service is also available on just about all other popular set-top hardware platforms. So don't need an Apple TV to watch Apple TV. It's a bit like Abbott and Costello's classic "Who's on First" routine.

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schwit1 shares a report from Hackread: On October 3, 2025, Hackread.com published an in-depth report in which hackers claimed to have stolen 989 million records from 39 major companies worldwide by exploiting a Salesforce vulnerability. The group demanded that Salesforce and the affected firms enter negotiations before October 10, 2025, warning that if their demands were ignored, they would release the entire dataset. The hackers, identifying themselves as "Scattered Lapsus$ Hunters," a collective said to combine elements of Scattered Spider, Lapsus$, and ShinyHunters, have now published data allegedly belonging to 6 of the 39 targeted companies. The companies named in the leak are as follows: Fujifilm, GAP, INC., Vietnam Airlines, Engie Resources, Quantas Airways Limited, and Albertsons Companies, Inc. In all 6 leaks, the record contains personal details of customers, business, including email addresses, full names, addresses, passport numbers, phone numbers. The hackers said on Telegram that they will not be releasing any additional information, stating, "A lot of people are asking what else will be leaked. Nothing else will be leaked. Everything that was leaked was leaked, we have nothing else to leak, and obviously, the things we have cannot be leaked for obvious reasons."

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NASA's Jet Propulsion Laboratory is laying off around 550 employees, or roughly 11% of its workforce, as part of an effort to "restructure and establish an appropriate size to ensure future success." According to JPL Director Dave Gallagher, the job cuts "are not related to the current government shutdown." CNBC reports: JPL is a research and development lab funded by NASA -- the federal space agency -- and managed by the California Institute of Technology. "While not easy, I believe that taking these actions now will help the Lab transform at the scale and pace necessary to help achieve humanity's boldest ambitions in space," Gallagher wrote in a separate mekor to JPL employees and contractors. Gallagher, in the public announcement, noted that the reorganization of JPL began in July, and "over the past few months, we have communicated openly with employees about the challenges and hard choices ahead." "This week's action, while not easy, is essential to securing JPL's future by creating a leaner infrastructure, focusing on our core technical capabilities, maintaining fiscal discipline, and positioning us to compete in the evolving space ecosystem -- all while continuing to deliver on our vital work for NASA and the nation," Gallagher wrote. Gallagher said that JPL employees will be notified of their status on Tuesday, and the "new Lab structure ... will become effective Wednesday."

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An anonymous reader quotes a report from The Register: Security researchers have resurrected a 12-year-old data-stealing attack on web browsers to pilfer sensitive info from Android devices. The attack, dubbed Pixnapping, has yet to be mitigated. Conceptually, it's the equivalent of a malicious Android app being able to screenshot other apps or websites. It allows a malicious Android application to access and leak information displayed in other Android apps or on websites. It can, for example, steal data displayed in apps like Google Maps, Signal, and Venmo, as well as from websites like Gmail (mail.google.com). It can even steal 2FA codes from Google Authenticator. "First, the malicious app opens the target app (e.g., Google Authenticator), submitting its pixels for rendering," explained [Alan Wang, a PhD candidate at UC Berkeley]. "Second, the malicious app picks the coordinates of a target pixel whose color it wants to steal. Suppose for example it wants to steal a pixel that is part of the screen region where a 2FA character is known to be rendered by Google Authenticator, and that this pixel is either white (if nothing was rendered there) or non-white (if part of a 2FA digit was rendered there). Third, the malicious app causes some graphical operations whose rendering time is long if the target pixel is non-white and short if it is white. The malicious app does this by opening some malicious activities (i.e., windows) in front of the target app. Finally, the malicious app measures the rendering time per frame of the above graphical operations to determine whether the target pixel was white or non-white. These last few steps are repeated for as many pixels as needed to run OCR over the recovered pixels and guess the original content." The researchers have demonstrated Pixnapping on five devices running Android versions 13 to 16 (up until build id BP3A.250905.014): Google Pixel 6, Google Pixel 7, Google Pixel 8, Google Pixel 9, and Samsung Galaxy S25. Android 16 is the latest operating system version. Other Android devices have not been tested, but the mechanism that allows the attack to work is typically available. A malicious Android app implementing Pixnapping would not require any special permissions in its manifest file, the authors say. The researchers detail the attack in a paper (PDF) titled "Pixnapping: Bringing Pixel Stealing out of the Stone Age."

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SpaceX's Starship megarocket successfully completed its 11th test flight, achieving major milestones like engine relight, satellite deployment, and a controlled splashdown in the Indian Ocean. From a report: This mission marks the second clean test run for Version 2, following a successful showing during its last test mission in August. Earlier this year, however, Starship Version 2 suffered three in-flight failures and an explosive accident during ground testing. Today's test mission is expected to be the last for the current iteration of Starship prototypes. The company has said it will debut a scaled up Version 3 for the next flight. You can watch a recording of the launch on YouTube.

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